Scientific Research

A collection of summaries of peer-reviewed articles on developments in stem cell science. (From the ISSCR Web site's Briefings page.)

• Human Embryonic Stem Cells Provide Clues about Fetal Heart Progenitors
  Posted May 28, 2008
  Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008). Human cardiovascular progenitor cells develop from a KDR(+) embryonic-stem-cell-derived population. Nature. doi:10.1038/nature06894.
  
  
• Tissue Engineering to Build a Heart
  Posted April 28, 2008
  Ott, H. C., Matthiesen, T. S., Goh, S. K., Black, L. D., Kren, S. M., Netoff, T. I., and Taylor, D. A. (2008). Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med 14, 213-221.
  
  
• Mice Pave the Way to Insights About Sickle Cell Anemia
  Posted March 21, 2008
  Hanna, J., Wernig, M., Markoulaki, S., Sun, C. W., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L. C., Townes, T. M., Jaenisch, R. (2007). Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318, 1920-1923.
  
  
• Breakthroughs in stem cell biology: Human iPS cells
  Posted February 27, 2008
  Park, I. H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., and Daley, G. Q. (2008). Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451, 141-146.
  Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920.
  
  
• Peeking at stem cells in the brain
  Posted February 26, 2008
  Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F., Benveniste, H., Djuric, P. M., Enikolopov, G., and Maletic-Savatic, M. (2007). Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318, 980-985.
  
  
• Nuclear Transfer Skin Cells from Monkey
  Posted February 26, 2008
  Byrne JA, Pedersen DA, Clepper LL, Nelson M, Sanger WG, Gokhale S, Wolf DP, Mitalipov SM (2007). Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature 450, 497-502.
  
  
• Mouse Adult Skin Cells Reprogrammed to Embryonic State
  Posted August 21, 2007
  Maherali, N., et al. (2007). Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1, 55-70
  Okita, K., et al. (2007). Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317.
  Wernig, M., et al. (2007). In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324
  

• Ethics and Biology of Germ Cells
  Posted May 1, 2007
  McLaren, A. (2007). Free-range eggs? Science 316, 339.
  

• Human Stem Cells Improve Mouse Neurodegenerative Disease
  Posted April 5, 2007
  Lee, J. P., et al. (2007). Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med.
  
  
• Mapping the Elusive MAPC: Questions settled about a powerful stem cell
  Posted February 2, 2007
  Serafini, M., et al. (2007). Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med 204, 129-139.
  
  
• Versatile Stem Cell Identified in Amniotic Fluid
  Posted January 24, 2007
  De Coppi, P., et al. (2007). Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 25, 100-106.
  

• Scientists Discover Master Regulator for Embryonic Stem Cells
  Posted October 16, 2006
  
  
• Report of the Formation of Human Embryonic Stem Cells from Single Cells Extracted from 8-10-cell Early Human Embryos
  Posted September 29, 2006
  
  
• Modified Human Embryonic Stem Cells Can Preserve Visual Function in
  Diseased Rat Retina
  Posted September 29, 2006
  
  
• Scientists Report Reprogramming of Adult Cells
  Posted September 20, 2006

Updated July 25, 2008

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